The observed insufficient a substantial accumulation of PHN in Mind next the intraventricular administration of (+)-amphetamine as well as development of considerable amounts of PHN from (+)-POH in brain tissue in vivo supports the view the aromatic hydroxylation of amphetamine pursuing its systemic administration takes place predominantly within the periphery, and that POH is then transported from the blood-Mind barrier, taken up by noradrenergic neurones in Mind where (+)-POH is transformed in the storage vesicles by dopamine β-hydroxylase to PHN. ^
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